Three shareholders in Cyclezyme have crossed disclosure thresholds following the company's directed share issue of 228,567 shares, according to a press release.Peter Falck and Javier Linares Pastén have retained unchanged holdings, but due to dilution, their holdings have decreased from 15.21 to 13.98 percent, thereby falling below the 15-percent threshold. Jens Olsson's holding has increased from 118,119 to 175,261 shares. This means that his ownership has risen from 4.56 to 6.22 percent and that he has crossed the 5-percent threshold.